The profile manager, and other associated pop-up windows (TX profile, mic profile) have vanished. It may be that they are still showing somewhere, but outside of the screen boundaries. How to get them back?
Could be off screen. First thing I try is changing the resolution and see if they come back.
If they are are showing up on your Task bar trying using the shift key and right clicking the task bar item and select move. Then use your arrow keys to see if you can steer the application back on to the screen.