HAM RADIO DELUXE PTT FLEX 6400

I am using MiniDeluxe which I have used in the past before and I have used HRD in the past with my old FLEX 3000.  Just got it as XMAS present and am trying to configure it for the FLEX 6400.  HRD is controlling everything on the radio and I am getting sound to the waterfall.   I have created a dedicated PORT in CAT and MiniDeluxe is connecting with no issues.  In HRD PTT settings, I am using Ham Radio Deluxe configuration.  After setting up the radio section, in HRD, the TX button will put the radio into transmit manually except I can't get it to go into TX when attempting to use the macros.   These are the default macros that come with the software.  This same thing happens when don't use MiniDeluxe and I try to use the HRD radio control window.  However, I prefer not to use that part of the software since it really isn't necessary with a FLEX.  I have tried all combinations of using different PTT settings in HRD and have had no progress towards the solution.  I must be missing something very simple.  Suggestions?

Thanks

Mark  KK2L