Wsjt-x config for Flex5000 running power SDR 2.8 and Ham radio deluxe

Harry, you'll need VSPE or VSPManager and VAC, depending on your OS. I like VSPE, as it runs without any problems on my Windows7 64bit machine. If you have them running, start MiniDeluxe and then PowerSDR.
Do not use HamRadioDeluxe itself, only DM780, HRDLog and the other subprograms, as MiniDeluxe acts as your server. Then use HamRadioDeluxe as the WSJTX settings, PTT on a separate virtual cable and there you are. Please look at the tutorials listed below. My own is for SmartSDR, but you can follow most of it, except vor VSPE and VAC, which you'll need for PowerSDR.
Vy 73, Alex - DH2ID
http://kc.flexradio.com/KnowledgebaseArticle50362.aspx
https://community.flexradio.com/flexradio/topics/tutorial-setting-up-wsjt-x-with-smartsdr