According to the manual section on profiles ANYTIME you change an existing setting in a Mic or Tx profile and resave that profile under the same name as before you made the changes then in order for a Global Profile to honor the new save changes in the Mic or Tx profile with the same name as the one it is assigned you MUST once again resave the Global Profile once you have changed and save the Mic or Tx profile with the same name the global profile has assigned.
Once this is done the next time the Global Profile is loaded or used you will see the new changes that you have made on the unit.
If you do not want to operate as you did with the settings from when you last shut it down you need to touch Menu and touch Profiles and choose the Global profile which contains the Mic and Transmit profiles you wish to have loaded and then press Load.
Remember if you create a Transmit profile in SSB on say 20m and set the power to 20watts, that is the ONLY band the 20 watts is set on. So for a transmit profile you need to sequence through every band on the active slice and set the power to 20 watts if you want the Transmit profile to use 20 watts on every band, then save it then resave the Global profiles which use that Transmit profile.
I guess you could also set a Maximum Power setting to do the same but looking at the manual it is not saved as perisistence or in any profiles so it would be easy to forget that I did that!