Just write down what you have created and remove them. You can also use the Windows snipping tool to do a screenshot of the CAT window.
Once you remove them install any hardware or USB serial devices and then recreate the ports.
My system has a 4 port PCI-e serial card, USB from PowerMaster II wattmeter, then CAT ports. I always put the physical first, followed by USB, then virtual.
If your referring to the spe console amp control program, I have mine connected to an actual hardware serial port on my PC, not a usb to serial converter. Also you might try the mini console app that can be downloaded from the spe yahoo group it has simple amp control features but no configuration capabilities.
The Remove button allows the user to remove a Port. Ctrl and Shift keys may be used to select multiple Ports for faster removal. Multiple selection does not apply to the Edit or Log buttons. Note that removing a FlexVSP Serial Port will result in those ports being removed from the system and may take several seconds to complete the device removal process.