I don't think this has been reported yet and nothing in the release notes. I have a 6500/V1.0.0. I am not able to transmit on ANT2. I can only receive on ANT2. Also, the RX slice panel only displays ANT1 with ANT2 is selected.
We just completed comprehensive testing on the FLEX-6500 with SmartSDR v1.0.0 and cannot reproduce this behavior. Please power down the FLEX-6500, remove DC power from the radio for a few minutes and then power everything back up and let me know if you still are experiencing the inability to transmit on ANT-2.