There is no reason why not, what was the specific issue? I have an ACOM 1000 driven by my 6300 with no issues at all. Just required the keying lead (phono to phono) and the TX delay set to 5ms and that was it. There was no need for a keying relay or ALC connection. Just remember to drop the drive :-) You could create a global profile that was 20~25w maybe that might help or use DDUtil!?