It should work fine. Set the Acom to use Kenwood CAT protocol. Make sure baud rate on both amp and SmartSDR matches. You will need a USB to setial cable with FTDI chipset plus a custom cable (see below). Flex sells the FTDI chip cables or you can order from Mouser, DigiKey or other online places. Be careful of Amazon and eBay as it may be a Chinese knockoff and may not work.