There are some correct answers here and some not so correct.
The Maestro can connect directly to the radio (any 6000 series) with just a LAN cable connected from the Maestro to the Radio in its simplest mode. Make sure the Maestro is powered from external 12v power as the LAN port is not active when the Maestro is running on 100% battery. No computer is required.
SmartSDR DAX or SmartSDR CAT is not required until you wish to use some logging or digital modes. Those can run on your computer at the same time as using the Maestro. If you chose this mode, then your Maestro needs to be LAN cabled into your home network (LAN Switch) so that the Maestro, PC and Radio can all communicate with each other.